London: A common bacteria that boosts digestive health can slow, and even reverse, build-up of a protein associated with Parkinson’s disease, according to a study. The study conducted in a Parkinson’s model of roundworms builds on previous research that links brain function to gut bacteria.
It identified a probiotic — or good bacteria — which prevents the formation of toxic clumps that starve the brain of dopamine, a key chemical that coordinates movement. The findings, published in the journal Cell Reports, could pave the way for future studies that gauge how supplements such as probiotics impact the condition.
In the brains of people with Parkinson’s, alpha-synuclein protein misfolds and builds up, forming toxic clumps. These clumps are associated with the death of nerve cells responsible for producing dopamine. The loss of these cells causes the motor symptoms associated with Parkinson’s, including freezing, tremors and slowness of movement.
The researchers from the University of Edinburgh, and the University of Dundee in the UK used roundworms altered to produce the human version of alpha-synuclein that forms clumps. They fed these worms with different types of over-the-counter probiotics to see if bacteria in them could affect the formation of toxic clumps.
The scientists found that a probiotic called Bacillus subtilis had a remarkable protective effect against the build-up of this protein, and also cleared some of the already formed protein clumps. This improved the movement symptoms in the roundworms. The researchers also found that the bacteria was able to prevent the formation of toxic alpha-synuclein clumps.
It did so by producing chemicals that change how enzymes in cells process specific fats called
sphingolipids, they said.
The research is the latest in a number of recent studies which found a link between brain function, and the thousands of different kinds of bacteria living in the digestive system, known as the gut microbiome.
Other studies into mice have found that the gut microbiome has an impact on the motor symptoms like limb movement. “The results provide an opportunity to investigate how changing the bacteria that make up our gut microbiome affects Parkinson’s,” said lead researcher Maria Doitsidou, from the University of Edinburgh. “The next steps are to confirm these results in mice, followed by fast-tracked clinical trials since the probiotic we tested is already commercially available,”